D reviews. Selection criteria: all randomized controlled trials of steroid treatment for acute spinal cord injury in any language. viagra without a doctor prescription
Data collection and analysis: one review author extracted data from trial reports. can you buy viagra in singapore Japanese and french studies were found through nascis and additional data (e. G. medicaresupplementspecialists.com/pfz-cheap-viagra-online-no-rx-yl/
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Main results: eight trials are included in this review, seven used methylprednisolone. buy viagra without prescription
Methylprednisolone sodium succinate has been shown to improve neurologic outcome up to one year post-injury if administered within eight hours of injury and in a dose regimen of: bolus 30mg/kg over 15 minutes, with maintenance infusion of 5. 4 mg/kg per hour infused for 23 hours. can you buy viagra from the chemist The initial north american trial results were replicated in a japanese trial but not in the one from france. Data was obtained from the latter studies to permit appropriate meta-analysis of all three trials. This indicated significant recovery in motor function after methylprednisolone therapy, when administration commenced within eight hours of injury. order viagra
A more recent trial indicates that, if methylprednisolone therapy is given for an additional 24 hours (a total of 48 hours), additional improvement in motor neurologic function and functional status are observed. does viagra and alcohol mix This is particularly observed if treatment cannot be started until between three to eight hours after injury. The same methylprednisolone therapy has been found effective in whiplash injuries. A modified regimen was found to improve recovery after surgery for lumbar disc disease. The risk of bias was low in the largest methyprednisolne trials. Overall, there was no evidence of significantly increased complications or mortality from the 23 or 48 hour therapy. Authors' conclusions: high-dose methylprednisolone steroid therapy is the only pharmacologic therapy shown to have efficacy in a phase three randomized trial when administered within eight hours of injury. One trial indicates additional benefit by extending the maintenance dose from 24 to 48 hours, if start of treatment must be delayed to between three and eight hours after injury. There is an urgent need for more randomized trials of pharmacologic therapy for acute spinal cord injury. This record should be cited as: bracken mb. Steroids for acute spinal cord injury. where to buy viagra in london Cochrane database of systematic reviews 2012, issue 1. Art. cheap viagra with prescription No. : cd001046. Doi: 10. 1002/14651858. Cd001046. Pub2 assessed as up to date: august 2, 2011 health topics: neurology > spinal cord injury orthopaedics & trauma > spinal cord injury more like. can you buy viagra in singapore lowest price on generic viagra
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